Chifukwa chiyani Albumin-bound paclitaxel siyenera kusinthidwa?

Pakalipano, pali mitundu itatu ya kukonzekera kwa paclitaxel pamsika ku China, kuphatikizapo jekeseni wa paclitaxel, Liposomal paclitaxel ndi Albumin-bound paclitaxel. omangidwa paclitaxel sakufunika kuthandizidwa?Tiyeni tiwone zotsatirazi.

Chifukwa chiyani Albumin-bound paclitaxel siyenera kupangidwa kale?

Jekeseni wa 1.Paclitaxel

Kuonjezera kusungunuka kwa madzi a paclitaxel, chosungunulira cha jekeseni wa paclitaxel chimapangidwa ndi mafuta a polyoxyethylene castor ndi ethanol. Asanagwiritse ntchito kuchipatala, glucocorticoids ndi antihistamines ayenera kugwiritsidwa ntchito pochiza.

2.Liposomal paclitaxel

Liposomal paclitaxel makamaka phospholipid bimolecular liposomes ndi awiri a 400 nm opangidwa ndi lecithin ndi mafuta m`thupi mu proportion.They mulibe polyoxyethylene castor mafuta ndi Mowa mtheradi kuti angayambitse ziwengo.

Komabe, kafukufuku wina wasonyeza kuti paclitaxel yokha ingayambitsenso hypersensitivity, zomwe zimagwirizana ndi kutsegula kwa chitetezo cha mthupi chomwe chimayendetsedwa ndi basophils, IgE ndi IgG. amafuna matupi awo sagwirizana pretreatment musanagwiritse ntchito.

3.Albumin-bound paclitaxel

Albumin-bound paclitaxel, yokhala ndi albumin yaumunthu monga chonyamulira, ili ndi ubwino wovunda mosavuta mu vivo, kudziunjikira mankhwala osokoneza bongo m'matumbo, kulunjika mwamphamvu komanso kuthandizira kwambiri kwa chemotherapy.

M'maphunziro a Gawo I, II kapena III pa albumin-bound paclitaxel, ngakhale kuti palibe chithandizo chomwe chinachitidwa, palibe kukhudzidwa kwakukulu kwa hypersensitivity komwe kunapezeka. .Chifukwa chake, chithandizo chamankhwala musanagwiritse ntchito paclitaxel yomangidwa ndi albumin sikuvomerezeka pakadali pano.

Zindikirani: Kuthekera komanso kugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zonse zachokera m'mabuku osindikizidwa.

Yunnan Hande Biotechnology Co., Ltd yakhala ikugwira ntchito yopangapaclitaxel APIkwa zaka zoposa 20, ndipo ndi mmodzi mwa opanga okha padziko lonse lapansi a paclitaxel API, mankhwala odana ndi khansa omwe amachokera ku zomera, ovomerezedwa ndi US FDA, European EDQM, TGA yaku Australia, Chinese CFDA, India, Japan ndi mabungwe ena olamulira dziko. .Hande ikhoza kupereka osati zapamwamba zokhapaclitaxel zopangira,komanso ntchito zokweza zaukadaulo zokhudzana ndi paclitaxel formulation.Kuti mumve zambiri, chonde omasuka kulankhula nafe pa 18187887160.