Kodi pali Ubale Wotani pakati pa Paclitaxel ndi Paclitaxel pa Injectable Suspension(Albumin Bound)?

Kodi paclitaxel,paclitaxel for injectable suspension and albumin-bound paclitaxel ndi chiyani?Magwiritsidwe ake akuluakulu ndi ati?Tiwafotokozera mwachidule m'nkhaniyi.

Paclitaxel:

Metabolite yachilengedwe yachiwiri yokhayokha komanso yoyeretsedwa ku khungwa, nthambi ndi masamba a gymnospermous taxus chinensis akhoza kulimbikitsa microtubule polymerization ndi kukhazikika kwa polymerized microtubules. ndi ntchito zosiyanasiyana za maselo, makamaka kuletsa magawano a selo pa siteji ya mitotic, ndi midadada yachibadwa kugawanika kwa maselo.

Ili ndi anti-chotupa yabwino ndipo imagwiritsidwa ntchito pochiza khansa ya m'mawere, khansa ya m'mapapo, khansa ya m'mawere, khansa ya mutu ndi khosi, khansa yofewa komanso khansa ya m'mimba.

Paclitaxel(Taxol) ndi anticancer API(Active Pharmaceutical Ingredient), yomwe siingagwiritsidwe ntchito mwachindunji ndi anthu.Iyenera kuperekedwa kumakampani akumunsi kapena mafakitale opanga mankhwala kuti akhale amodzi mwa API ya mankhwala omalizidwa.

Pakali pano, paclitaxel yomwe imagwiritsidwa ntchito kwambiri ndi jakisoni woletsa khansa ndi zida zamankhwala (kuphatikiza ma stents ndi mabaluni). Ndi chitukuko chofulumira chaukadaulo wa sayansi ya zamankhwala ndi zamankhwala, kugwiritsa ntchito paclitaxel kumawunikidwanso mosalekeza, komanso mikhalidwe yosiyana ya odwala nayonso ikufufuzidwa. Khulupirirani kuti posachedwapa, zidzakhala zotetezeka komanso zothandiza kwa madokotala ndi odwala, ndipo padzakhala mitundu yambiri ya mankhwala oletsa khansa omwe ali ndi paclitaxel omwe ali ndi mphamvu zowononga khansa.

Paclitaxel ya Kuyimitsidwa kwa Jakisoni:

Jakisoni wokhala ndi paclitaxel API.

Paclitaxel ya jakisoni imaphatikizapo jakisoni wa polyoxyethylene castor paclitaxel; jakisoni wa Liposome paclitaxel; jakisoni wa albumin womangidwa paclitaxel;Micellar paclitaxel ndi mitundu ina ya mlingo.

Amagwiritsidwa ntchito kwambiri pa khansa ya m'mawere, khansa ya m'mapapo, khansa ya m'mawere ndi matenda ena, ndipo ndi imodzi mwa mankhwala othandiza kwambiri pakalipano.

Albumin Bound Paclitaxel:

Jakisoni wa Albumin womangidwa paclitaxel ndikukonzekera kuphatikiza paclitaxel ndi albumin.Ndi ya paclitaxel ya jakisoni ndipo ndi imodzi mwa jakisoni wapaclitaxel wogwiritsidwa ntchito kwambiri wokhala ndi chitetezo chokwanira.

Albumin paclitaxel, yoyamba kulowa m'maso mwa anthu ndi jakisoni wa ABRAXANE(ABRAXANE For Injectable Suspension paclitaxel protein-bound particles for jekeseni, albumin-bound) yovomerezedwa ndi FDA mu 2005, yomwe imagwiritsidwa ntchito pochiza khansa ya m'mawere ya metastatic. Kuwonongekanso kuli pafupifupi 130 nm, ndipo kulibe zosungunulira zapoizoni. Chitetezo chake ndi zotsatira zake zochiritsira ndizokwera kwambiri kuposa zokonzekera zofananira, ndipo ndizotchuka kwambiri. Ndi chimodzi mwazifukwa zazikulu zofufuzira zamakampani akuluakulu azamankhwala m'tsogolomu.

Zimagwiritsidwa ntchito makamaka pochiza khansa ya m'mawere ya metastatic yomwe imalephera kuphatikizika kwa chemotherapy kapena khansa ya m'mawere yomwe imabwereranso mkati mwa miyezi 6 pambuyo pa adjuvant chemotherapy.

Yunnan Hande Bio-Tech wadzipereka pa kafukufuku & chitukuko ndi kupangapaclitaxel,docetaxel,10-DAB semisynthetic paclitaxel,ndicabazitaxel,ndipo ili ndi kafukufuku watsatanetsatane wa zonyansa zosiyanasiyana zomwe zili mu paclitaxel.Kuphatikiza apo, Hande imaperekanso ntchito zosinthira ukadaulo wokhudzana ndi paclitaxel: jakisoni wapaclitaxel wachikhalidwe; jakisoni wa Albumin womangidwa paclitaxel ndi zina, talandiridwa kuti mutifunse kuti tifunse!（Whatsapp/Wechat:+86 18187887160)