Kodi albumin-bound paclitaxel ndi chiyani?

Kodi albumin-bound paclitaxel ndi chiyani?Albumin-bound paclitaxel (yomwe imadziwika kuti albumin paclitaxel, yomwe imafupikitsidwanso kuti Nab-P) ndi paclitaxel nanoformulation yatsopano, yomwe imadziwika padziko lonse lapansi ngati mapangidwe apamwamba kwambiri a paclitaxel.Imaphatikiza endogenous albumin yamunthu ndi paclitaxel mu mawonekedwe osagwirizana ndipo ma nanoparticles omwe amachokera kugonjetseratu kuipa kwa paclitaxel kukhala osasungunuka m'madzi, popanda kufunikira kwa mafuta a polyoxyethylene castor kapena Tween 80 ngati chosungunulira.Popeza albumin ndi mankhwala achilengedwe achilengedwe, ili ndi maubwino okhala otetezeka, osavulaza, osateteza chitetezo chathupi, osawonongeka, komanso ogwirizana.

Chifukwa chiyani albumin-bound paclitaxel ndiyotsogola kwambiri?

1. Palibe co-solubilizationno chisanadze mankhwala

Kutenga mapuloteni a plasma achilengedwe, amamanga mamolekyu a hydrophobic paclitaxel m'njira yosagwirizana popanda kusungunulira, kuthetsa hypersensitivity ndi kawopsedwe kawo chifukwa cha zosungunulira, motero amachotsa kufunikira kwa pretreatment ya mahomoni musanagwiritse ntchito ndikufupikitsa nthawi ya kulowetsedwa. mpaka mphindi 30, kufupikitsa kwambiri kukhala m'chipatala kwa odwala oncology, komanso kumaliza chithandizo chamankhwala kudzera muchipatala cha masana.

2. Bwino pharmacokinetics

Poyerekeza ndi paclitaxel wamba, albumin paclitaxel imakhala ndi kugawa kwa minofu yofulumira komanso yapamwamba m'thupi, komanso kutulutsa pang'onopang'ono kuchokera kuzinthu, mlingo wolekerera m'thupi la munthu ukhoza kuwonjezeka kwambiri ndipo zotsatira zochiritsira zimakhala bwino kwambiri.

3. Kusankha chotupa m'deralo aggregation

Chimodzi mwazifukwa zomwe odwala ambiri amawopa mankhwala a paclitaxel chemotherapy ndikuti kugawa kwapaclitaxel m'matumbo a chotupa ndi minofu ina yokhazikika kumakhala kofanana, kumabweretsa zovuta zambiri.Mosiyana ndi izi, paclitaxel ili ndi "chotupa chosankha" mozizwitsa ndipo kuchuluka kwake m'matumbo a chotupa ndikokwera kwambiri kuposa minofu ina yabwinobwino.

Zindikirani: Zomwe zingachitike ndikugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zatengedwa m'mabuku osindikizidwa.

Yunnan Hande Bio-Tech Co., Ltd yakhala ikugwira ntchito popangapaclitaxel APIkwa zaka zoposa 20, ndipo ndi mmodzi mwa opanga padziko lonse lapansi a paclitaxel API ndi chivomerezo cha FDA, satifiketi ya CEP ndi satifiketi ya GMP ku China.Hande ikhoza kupereka osati paclitaxel API yapamwamba komansontchito yosinthira ukadaulo ya paclitaxel albumin.Kuti mudziwe zambiri, chonde omasuka kulankhula nafe pa 18187887160.