Kodi zotsatira za ceramide ndi ziti?

Kodi zotsatira za ceramide ndi ziti?Ceramidelimapezeka m'maselo onse a eukaryotic ndipo limagwira ntchito yofunikira pakuwongolera kusiyanasiyana kwa ma cell, kuchulukana, apoptosis, ukalamba ndi zochitika zina zamoyo.Ceramide, monga chigawo chachikulu cha intercellular lipids mu khungu stratum corneum, osati amachita ngati wachiwiri mthenga molekyulu mu sphingomyelin njira, komanso amathandiza kwambiri mapangidwe epidermal stratum corneum.Lili ndi ntchito zosunga zotchinga khungu, zonyowa, zotsutsana ndi ukalamba, zoyera komanso zochizira matenda.

Ceramide imakhala pafupifupi 40% mpaka 50% ya lipids mu stratum corneum yaumunthu.Ndilo gawo lalikulu la stratum corneum kuti ligwiritse ntchito zotchinga pakhungu, kunyowa ndi ntchito zina.Ntchito zake zakuthupi mu stratum corneum ndizo:
(1) Chotchinga cholepheretsa: ntchito yotchinga ya khungu la stratum corneum ikasokonekera, kaphatikizidwe ka sphingolipids kumawonjezeka, ndipo amafika pamtengo wapamwamba kwambiri akamaliza kukonza zotchinga.Kugwiritsiridwa ntchito kwapadera kwa ceramide yachilengedwe kapena yopangidwa kungathe kubwezeretsa kuwonongeka kwa ntchito yotchinga khungu chifukwa cha zosungunulira za organic kapena mankhwala opangidwa ndi surfactant.
(2) Kumamatira:ceramideimakhala mu intercellular lipids ya stratum corneum, ndipo imagwira ntchito yolumikizana ndi ma intercellular kudzera mu kuphatikiza kwa ester bond ndi mapuloteni apamwamba a cell.Pamene zili ceramide mu epidermis amachepetsa ndi zaka kapena zinthu zina, ndi adhesion wa keratinocytes mu stratum corneum amachepetsa, chifukwa mu lotayirira dongosolo la stratum corneum, kuchepa kwa khungu chotchinga ntchito, imfa ya madzi kudzera pakhungu, ndipo potsiriza kuyanika ndi ngakhale makulitsidwe a epidermis.
(3) Moisturizing zotsatira: pa nthawi yolumikiza keratinocytes mu stratum corneum, madzi mafuta amphiphilic a ceramide kupanga izo kupanga ena maukonde dongosolo mu stratum corneum, ndi khungu madzi akhoza kupulumuka.Zoyeserera zikuwonetsa kuti ceramide yapamutu imatha kukulitsa mawonekedwe a khungu, ndiye kuti, kuwonjezera kuchuluka kwa madzi, ndikuwongolera luso la khungu kusunga madzi.Panthawi imodzimodziyo, ceramide yotengedwa ku zomera ingathandizenso kuti khungu likhale lonyowa.
(4) Zotsutsana ndi ukalamba komanso zotsutsana ndi ziwengo: ndi kukalamba kwa khungu, kaphatikizidwe ka lipids pakhungu pang'onopang'ono kumachepa.Kuwonjezeka kwa ceramide kumatha kukulitsa makulidwe a cuticle ya epidermis ya khungu ndikuwongolera "mapangidwe a khoma la njerwa" la cuticle, kuti khungu likhale lolimba, kuteteza kutulutsa makwinya, ndikuchedwetsa kukalamba kwa khungu. khungu.Ntchito yotchinga pakhungu ikasokonekera, zimatha kuyambitsa zinthu zovulaza zakunja kuti zilowe pakhungu kudzera m'malo anyanga ndi ma follicles atsitsi, zomwe zimayambitsa ziwengo.Ndi kuwonjezeka kwa ceramide, khungu limakalamba, ndipo kaphatikizidwe ka lipid pakhungu pang'onopang'ono kumachepa ndi zaka.Kuwonjezeka kwa zinthu za ceramide kumatha kukulitsa makulidwe a nyanga za epidermis, kusintha "makoma a njerwa" pansanjika ya nyanga, kuti khungu likhale lofewa, kuteteza kubadwa kwa makwinya, ndikuchedwetsa kukalamba kwa khungu. khungu.
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