Kodi ubwino wa paclitaxel polymer micelles ndi chiyani?

Tikudziwa kuti mitundu ya paclitaxel yomwe yagulitsidwa ikuphatikizapo jakisoni wa paclitaxel, liposomal paclitaxel, docetaxel, ndi albumin-bound paclitaxel.Kodi ubwino wa paclitaxel ndi paclitaxel polymer micelles ndi chiyani?Tiyeni tione zotsatirazi.

Ubwino wa paclitaxel polymer micelles

1. Copolymer imadziphatikiza yokha m'madzi kuti ipange nanocarrier yokhala ndi "core-shell".Nyukiliya encapsulated paclitaxel ya micelle sichinawonongeke, kotero kuti ikhoza kutenga nawo mbali m'magazi kwa nthawi yaitali.

2. Tinthu tating'onoting'ono ta polima micellar paclitaxel (18-20nm), zomwe zimatha kulunjika ku chotupa cha microenvironment ndi kusokonezeka kwa mitsempha.Mwanjira imeneyi, mankhwalawa amatha kukhalabe m'matumbo a chotupa, zomwe zimapangitsa kuti minyewa yake ikhale yayikulu mu minofu ya chotupa komanso ndende yotsika mu minofu yabwinobwino.Ngakhale kuwongolera magwiridwe antchito, kuchuluka kwa zotsatira zoyipa kumachepetsedwa.

Kugwiritsa ntchito paclitaxel polima micelles ku China

Mu Okutobala 2021, China National Drug Administration (NMPA) idalengeza kuti paclitaxel polymer micelle yoyamba ku China idavomerezedwa, ndipo chikuwonetsa kuti ndi khansa ya m'mapapo yopanda yaying'ono.

Zindikirani: Mphamvu zomwe zingagwiritsidwe ntchito komanso zomwe zafotokozedwa m'nkhaniyi zonse zachokera m'mabuku osindikizidwa.

Yunnan Hande Biotechnology Co., Ltd yakhala ikugwira ntchito pakupangapaclitaxel APIkwa zaka zoposa 20, ndipo ndi mmodzi mwa opanga okha padziko lonse lapansi a paclitaxel API, mankhwala oletsa khansa omwe amachokera ku zomera, ovomerezedwa ndi US FDA, European EDQM, TGA yaku Australia, Chinese CFDA, India, Japan ndi mabungwe ena olamulira dziko. .Hande angapereke osati apamwamba kwambiripaclitaxel zopangira, komanso ntchito zokweza zaukadaulo zokhudzana ndi kapangidwe ka paclitaxel.Kuti mudziwe zambiri, chonde omasuka kulankhula nafe pa 18187887160.