Paclitaxel, mankhwala achilengedwe otengedwa ku fir yofiyira, amalepheretsa chotupa cell mitosis pochita mapuloteni a microtubule.Ndiwoyimira woimira gulu la paclitaxel ndipo ndiye mankhwala oyamba opangidwa kuchokera ku chomera chachilengedwe kulandira chivomerezo cha FDA chochizira mitundu yosiyanasiyana ya khansa, kuphatikiza khansa ya m'mawere, m'mawere, mapapo, sarcoma ya Kaposi, khansa ya khomo pachibelekero ndi kapamba.Mzaka zaposachedwa,paclitaxelyatchukanso chifukwa chogwiritsa ntchito pazida zamankhwala.Tiyeni tione m’nkhani yotsatirayi.
Ntchito zapaclitaxelm'zida zamankhwala
Paclitaxel, kupyolera mu polymerization imodzi ndi α (α-tubulin) ndi β (β-tubulin) ya microtubulin, imayambitsa ma microtubules ambiri kuti apange polymeriza mosadziwika bwino, zomwe zimapangitsa kusintha kwa chigoba chofanana cha maselo ndi kutayika kwa ntchito yabwino, kuchititsa kuti chitukuko cha maselo chiyime mu gawo la G0 / G1 ndi gawo la G1 ndi GM, ndipo ma cell mitosis aletsedwe mu mitotic gawo, potsirizira pake kukwaniritsa kulepheretsa kugawanika kwa mitsempha yosalala ya minofu, kufalikira Zotsatira zake ndikuletsa kugawanika ndi kufalikira kwa mitsempha yosalala ya mitsempha. ndikuletsa restenosis kuti isachitike.
1. Paclitaxelmankhwala stent
Drug-eluting stent (DES) ndi stent yomwe imagwiritsa ntchito chitsulo chopanda zitsulo kuti chinyamule (kunyamula) anti-endothelial proliferation drug, yomwe imatulutsidwa ndi kutulutsa kwanuko m'chombo kuti mulepheretse kufalikira kwa endothelial kuti muteteze restenosis mu stent.Kugwiritsa ntchito bwino kwa mankhwala opangira mankhwala osokoneza bongo kunachepetsa kwambiri chiwerengero cha restenosis ndi kubwezeretsanso, koma sikunachepetse chiwerengero cha matenda ndi imfa.Panalibe kusiyana kwakukulu pazochitika za zochitika zomaliza zachipatala pakati pa mankhwala-eluting stents, ndi mapeto ena achiwiri amapindula.Ma stents otulutsa mankhwala amaphatikizanso ma stents opangidwa ndi chitsulo chosapanga dzimbiri kapena cobalt-chromium omwe amakutidwa ndi antiproliferative mankhwala onyamula okhala ndi zokutira zoperekera mankhwala za polymeric kuphatikiza umisiri wokhazikika, wowonongeka, komanso umisiri wopanda polima wopanda mankhwala operekera mankhwala, ndipo uli ndi mankhwala kuphatikiza limoxylates ndi paclitaxel.Pakadali pano, ma stents a mankhwala a paclitaxel amagwiritsidwa ntchito kwambiri pochiza matenda osiyanasiyana amitsempha yamagazi, intracranial, carotid, aimpso ndi mitsempha yachikazi.
2. Mabaluni okutidwa ndi mankhwala a Paclitaxel
Baluni yokhala ndi mankhwala osokoneza bongo (DCB), monga njira yatsopano yopititsira patsogolo komanso yokhwima, yatsimikiziridwa m'mayesero angapo azachipatala chifukwa cha mphamvu yake ndi chitetezo ku ISR, zilonda za intracoronary stenosis, zotupa zazing'ono zotengera, zilonda za bifurcation, ndi zina zotero.
Zindikirani: Kuthekera komanso kugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku osindikizidwa.
Kuwerenga kowonjezereka:Yunnan Hande Biotechnology Co., Ltd. yakhala ikuyang'ana kwambiri pakupanga paclitaxel kwa zaka 28.Ndiwodzipangira yekha padziko lonse lapansi wopanga mankhwala oletsa khansa a paclitaxel omwe avomerezedwa ndi US FDA, European EDQM, Australian TGA, China CFDA, India, Japan ndi mabungwe ena olamulira dziko.bizinesi.Ngati mukufuna kugulaPaclitaxel API, chonde titumizireni pa intaneti.
Nthawi yotumiza: Oct-09-2022