Paclitaxel ndi mankhwala abwino kwambiri achilengedwe odana ndi khansa omwe apezeka pano. Amagwiritsidwa ntchito kwambiri pochiza khansa ya ovarian, khansa ya m'mawere, khansa ya m'mapapo, zotupa zapamutu ndi khosi, khansa yam'mero, khansa ya m'mimba ndi sarcoma yofewa.Paclitaxelchakopa chidwi kwambiri kuchokera kwa asayansi chifukwa cha kapangidwe kake ka mankhwala, njira zapadera zogwirira ntchito, zodalirika zothana ndi khansa, komanso kusowa kwakukulu kwazinthu. kaphatikizidwe ka paclitaxel, ndipo mpikisano ndi woopsa kwambiri, womwe wakhala cholinga cha organic synthetic chemistry kumapeto kwa zaka za zana la 20.
Makina apadera odana ndi chotupa a paclitaxel
Paclitaxel imatha kupanga Tubulin ndi Tubulin dimer zomwe zimapanga ma microtubules kutaya mphamvu yamphamvu, kulimbikitsa ndikulimbikitsa Tubulin polymerization, msonkhano wa microtubule, ndikuletsa depolymerization, kuti akhazikitse ma microtubules ndikuletsa Mitosis ya maselo a khansa ndikuyambitsa apoptosis, potero kupewa kufalikira kwa khansa. ma cell ndikusewera gawo lodana ndi khansa.
M'malo mwake, Tubulin, yomwe imagwirizana kwambiri ndi cell Mitosis, imapezeka pafupifupi padziko lonse lapansi m'maselo onse a eukaryotic. Amatha kupanga ma microtubules mosinthika. Kupatukana kwa chromosome kumafuna thandizo la ma microtubules awa. Kuwonongeka kwa nyundo ngati ma microtubules kumatha kupha maselo ndi magawano osadziwika bwino. Mankhwala ena odana ndi khansa, monga colchicine, Vinblastine, Vincristine, amagwira ntchito yolimbana ndi chotupa poletsa Tubulin ku polymerization.
Mosiyana ndi anti-Mitosis ndi anti-chotupa mankhwala,paclitaxelndi mankhwala oyamba omwe amapezeka kuti amatha kuyanjana ndi polima ya Tubulin, ndiko kuti, imagwira ntchito pophatikizana kwambiri ndi ma microtubules kuti azikhala okhazikika. kutulukira kumeneku kwakopa akatswiri ambiri a zamoyo kuti agwiritse ntchitopaclitaxelmonga chida chofufuzira mu biomedicine, kuyang'ana magawo osadziwika a ma cell ndikupeza njira zatsopano zopangira mankhwala oletsa khansa.
Kufotokozera: Mphamvu zomwe zingagwiritsidwe ntchito ndi zomwe zatchulidwa m'nkhaniyi zonse zachokera m'mabuku opezeka pagulu.
Yunnan Hande Bio-tech yakhala ikuyang'ana kwambiri pakupanga paclitaxel kwa zaka 28.Ndi bizinesi yodziyimira payokha ya paclitaxel zopangira, zomwe zavomerezedwa ndi mabungwe olamulira dziko monga FDA ku United States, EDQM ku Europe, TGA ku Australia, CFDA ku China, India, ndi Japan.Yunnan Handepaclitaxellikupezeka mu katundu ndipo amagulitsidwa mwachindunji ndi opanga.Takulandilani kuti mufunse.
Nthawi yotumiza: Jun-12-2023