Mankhwala a Paclitaxel amatengedwa ngati njira yoyamba yothandizira khansa ya m'mawere, ndipo amagwiritsidwa ntchito kwambiri pachipatala cha khansa ya ovary, khansa ya m'mapapo, zotupa za mutu ndi khosi, khansa ya m'mikodzo, khansa ya m'mimba ndi sarcoma yofewa.M'zaka zaposachedwa, kudzera mu kufufuza kosalekeza kwa mankhwala a paclitaxel ndikusintha kosalekeza kwa kapangidwe kake, mankhwalawa tsopano akuphatikizapo jekeseni wa paclitaxel, docetaxel (docetaxel), liposomal paclitaxel ndi albumin-bound paclitaxel.Ndiye pali kusiyana kotani pakati pa mankhwalawa paclitaxel, tiyeni tiphunzire zambiri za iwo pansipa.
I. Kusiyana kwa ntchito zoyambira
1. Jakisoni wa Paclitaxel: Amasonyezedwa pamzere woyamba komanso wotsatira wotsatira wa khansa ya ovarian yopita patsogolo, chithandizo chothandizira khansa ya m'mawere ya lymph node-positive pambuyo pa regimen yokhazikika ya adriamycin yokhala ndi kuphatikiza mankhwala amphamvu a chemotherapy, khansa ya m'mawere mu khansa ya m'mawere ya metastatic. walephera kuphatikiza mankhwala amphamvu a chemotherapy kapena kubwereranso m'miyezi 6 ya chithandizo chamankhwala adjuvant chemotherapy, chithandizo choyamba cha khansa ya m'mapapo yopanda maselo ang'onoang'ono, komanso chithandizo chachiwiri cha khansa yokhudzana ndi AIDS.
2. Docetaxel: Pochiza khansa ya m'mawere yapamwamba kapena ya metastatic yomwe yalephera kale mankhwala amphamvu;pochiza khansa yapamwamba kapena ya metastatic yomwe siing'ono yama cell ya m'mapapo yomwe yalephera ndi cisplatin-based chemotherapy.Zimagwiranso ntchito pa khansa ya m'mimba ndi khansa ya prostate.
3. Liposomal paclitaxel: Itha kugwiritsidwa ntchito ngati njira yoyamba yothandizira khansa ya ovarian komanso njira yoyamba yothandizira khansa ya ovarian metastatic, ndipo ingagwiritsidwenso ntchito limodzi ndi cisplatin.Itha kugwiritsidwanso ntchito potsata chithandizo chotsatira cha odwala khansa ya m'mawere omwe adalandira chithandizo chamankhwala chokhazikika chomwe chili ndi adriamycin kapena kuchiza odwala omwe abwereranso.Itha kugwiritsidwanso ntchito limodzi ndi cisplatin ngati chemotherapy yoyamba kwa odwala omwe ali ndi khansa ya m'mapapo yopanda maselo ang'onoang'ono omwe sangathe kuthandizidwa ndi opaleshoni kapena radiotherapy.
4. Albumin-bound paclitaxel: yosonyezedwa pochiza khansa ya m'mawere ya metastatic yomwe yalephera kuphatikiza mankhwala amphamvu amphamvu kapena khansa ya m'mawere yomwe yabwereranso mkati mwa miyezi 6 pambuyo pa adjuvant chemotherapy.Pokhapokha ngati pali contraindication, mankhwala am'mbuyomu ayenera kukhala ndi anthracycline anticancer agent.
II.Kusiyana kwa chitetezo cha mankhwala
1. Paclitaxel: kusasungunuka kwamadzi.Nthawi zambiri, jekeseni adzawonjezera surfactants polyoxyethylene-m'malo Kastor mafuta ndi Mowa kusintha solubility wa paclitaxel m'madzi, koma histamine amamasulidwa pamene polyoxyethylene m'malo Kastor mafuta ndi oipa mu vivo, zomwe zingachititse kuti matupi awo sagwirizana ndipo akhoza kukulitsa. The neurotoxicity ya paclitaxel, ndipo imatha kukhudzanso kufalikira kwa mamolekyu a mankhwala ku minofu ndikukhudza anti-chotupa.
2. Docetaxel: kusungunuka kwamadzi kumakhala kochepa, ndipo kumafunika kusungunuka powonjezerapo polysorbate 80 ndi anhydrous ethanol, zonse zomwe zimatha kuonjezera zochitika zowawa ndipo zingayambitse kusagwirizana ndi hemolytic.
3. Liposomal paclitaxel: mankhwalawa amaikidwa mu lipid-ngati bilayers kuti apange ma vesicles ang'onoang'ono, ndipo mankhwalawa amapangidwa ndi tinthu tating'onoting'ono ta liposomal popanda polyoxyethylene-substituted castor mafuta ndi anhydrous ethanol, zomwe zimayambitsa ziwengo.Komabe, kafukufuku wasonyeza kuti mankhwala a paclitaxel pawokha amatha kuyambitsanso kukhudzidwa kwa hypersensitivity, koma pamlingo wocheperako poyerekeza ndi jakisoni wa paclitaxel.Pakadali pano, paclitaxel liposomes amafunikirabe chithandizo chamankhwala chodziwikiratu musanagwiritse ntchito.
4. Albumin-bound paclitaxel: Paclitaxel albumin lyophilized agent yatsopano yogwiritsira ntchito albumin yaumunthu monga chonyamulira mankhwala ndi stabilizer, yomwe ilibe co-solvent polyoxyethylene-substituted castor mafuta ndipo imakhala ndi paclitaxel yotsika kwambiri yokhala ndi paclitaxel liposomes, ndipo alibe amafuna chithandizo asanalandire chithandizo.
Zindikirani: Zomwe zingatheke komanso momwe mungagwiritsire ntchito ulalikiwu zachokera m'mabuku osindikizidwa.
Yunnan Hande Biotechnology Co., Ltd yakhala ikugwira ntchito pakupangapaclitaxel APIkwa zaka zoposa 20, ndipo ndi mmodzi mwa opanga okha padziko lonse lapansi a paclitaxel API, mankhwala oletsa khansa omwe amachokera ku zomera, ovomerezedwa ndi US FDA, European EDQM, TGA yaku Australia, Chinese CFDA, India, Japan ndi mabungwe ena olamulira dziko. .Hande angapereke osati apamwamba kwambiripaclitaxel zopangira, komanso ntchito zokweza zaukadaulo zokhudzana ndi kapangidwe ka paclitaxel.Kuti mudziwe zambiri, chonde omasuka kulankhula nafe pa 18187887160.
Nthawi yotumiza: Dec-08-2022