Kukutengerani njira ya kaphatikizidwe paclitaxel

Paclitaxel ndi metabolite yachiwiri yachilengedwe yodzipatula ndikuyeretsedwa ku khungwa la fir yofiyira.Zatsimikiziridwa mwachipatala kuti zimakhala ndi zotsatira zabwino zotsutsana ndi zotupa, makamaka pa ovarian, chiberekero ndi khansa ya m'mawere, yomwe imakhala ndi khansa yambiri.Pakadali pano,paclitaxel zachilengedwendipo semi-synthetic paclitaxel ikupezeka pamsika.Nkhani yotsatira idzakutengerani njira ya paclitaxel synthesis.

Paclitaxelamachotsedwa ku khungwa ndi masamba a chomera ichi, ndipo ndondomeko yochotsamo imakhala yovuta kwambiri, yosasungunuka m'madzi ndi mowa, ndipo zomwe zili ndi zochepa kwambiri, 100g yokha, mwachitsanzo, matani awiri a paclitaxel, akhoza kuchotsedwa ku matani 30 a khungwa louma. .Ngakhale kuti kaphatikizidwe kake kake ka mankhwala kamalizidwe mu labotale, kumakhudza njira zambiri, zovuta zomwe zimachitika, kukwera mtengo komanso zokolola zochepa.Chifukwa chake, sikuthekabe kuzipanga m'mafakitale pogwiritsa ntchito mankhwala ophatikizika, zomwe zimapangitsa kuti zikhale zodula kwambiri.

Popeza zachilengedwepaclitaxelamachotsedwa ku Pacific yew, yomwe ndi gwero losowa, ndipo kukula kwa yew zachilengedwe ndi yayitali, pafupifupi 13.6 kg ya khungwa kuti ichotse 1 gramu ya paclitaxel, ndi mitengo ya yew 3-12 yazaka 100 imayenera kuchiza ovarian imodzi. wodwala khansa, kupezeka kwanthawi yayitali komanso kukwera mtengo kwadzetsa chitukuko chofulumira chaukadaulo wapaclitaxel.

Pakadali pano, njira yayikulu yopangira paclitaxel synthesis ndi bioengineering njira, yomwe imadziwikanso kuti paclitaxel semisynthesis.Njira ya bioengineering imagwiritsidwa ntchito popanga paclitaxel pamlingo waukulu mwa kuswana ndi kuyang'ana zovuta zomwe zimatha kutulutsa kuchuluka kwa paclitaxel, ndiyeno mwakuwakulitsa mosalekeza, kusintha ndi kukhathamiritsa ma genetic awo, paclitaxel imatha kupangidwa mwanjira yachikhalidwe "popanda kuchepetsa”, ndipo sikulinso malire ndi kusowa kwa zipangizo.Zotsatira zaposachedwa kwambiri za kafukufukuyu zikuwonetsa kuti kaphatikizidwe kabwino kachitidwe kawongoleredwa bwino kwambiri chifukwa cha kutulutsa kwakukulu kwa ma micrograms 448.52 a paclitaxel pa lita imodzi ya sing'anga ya chikhalidwe.

Kuphatikizika kwa mankhwala, ngakhale kumalizidwa, sikuli kofunikira m'mafakitale chifukwa chazovuta zomwe zimafunikira, zokolola zochepa, komanso kukwera mtengo.Njira ya semi-synthetic ya paclitaxel tsopano ndi yokhwima kwambiri ndipo imatengedwa kuti ndi njira yabwino yowonjezeretsa gwero la paclitaxel kupatula kulima mopanga.Njira ya semi-synthetic imatha kugwiritsa ntchito kwambiri zomera.

Zindikirani: Zomwe zingatheke komanso momwe mungagwiritsire ntchito pepalali zikuchokera m'mabuku osindikizidwa.

Kuwerenga kowonjezereka:Yunnan Hande Biotechnology Co., Ltd. yakhala ikuyang'ana kwambiri pakupanga paclitaxel kwa zaka 28.Ndiwodzipangira yekha padziko lonse lapansi wopanga mankhwala oletsa khansa a paclitaxel omwe avomerezedwa ndi US FDA, European EDQM, Australian TGA, China CFDA, India, Japan ndi mabungwe ena olamulira dziko.bizinesi.Ngati mukufuna kugulaPaclitaxel API, chonde titumizireni pa intaneti.