Paclitaxel ndi mankhwala achilengedwe otengedwa ku chomera cha yew, chomwe chili ndi ntchito yayikulu yolimbana ndi chotupa. fufuzani mozama zotsatira zochiritsira zapaclitaxelpa mitundu yosiyanasiyana ya khansa.
Kapangidwe ndi katundu wa paclitaxel
Paclitaxel ndi gulu lovuta la tetracyclic diterpenoid lomwe lili ndi mawonekedwe apadera atatu, omwe amapereka maziko a ntchito yake yotsutsana ndi chotupa.Mapangidwe ake a molekyulu ndi C47H51NO14, kulemera kwa mamolekyu ndi 807.9, ndipo ndi ufa wonyezimira wachikasu pa kutentha.
Njira yolimbana ndi khansa yapaclitaxel
Njira yolimbana ndi khansa ya paclitaxel imagwirizana kwambiri ndi kuletsa kwake kwa tubulin depolymerization ndi zotsatira zake pa kugawanika kwa maselo ndi kuchulukana. Kuphatikiza apo, paclitaxel imathanso kuyambitsa ma cell apoptosis ndikuletsa chotupa angiogenesis.
Machiritso a paclitaxel pamitundu yosiyanasiyana ya khansa
1. Khansara ya m'mawere: Chithandizo cha paclitaxel pa khansa ya m'mawere chadziwika kwambiri. Pakafukufuku wa odwala 45 omwe ali ndi khansa ya m'mawere, paclitaxel pamodzi ndi mankhwala amphamvu a chemotherapy anachititsa kuti chotupa chichepetse mu 41% ya odwala komanso kukhala ndi moyo pafupifupi miyezi yoposa 20.
2.Kansa ya m'mapapo ya m'mapapo yosakhala yaying'ono:Pakansa ya m'mapapo yomwe siing'ono,paclitaxel kuphatikiza ndi platinamu mankhwala amphamvu atha kupititsa patsogolo kupulumuka kwa odwala. chemotherapy idapangitsa kupulumuka kwapakati kwa miyezi 12.
3. Khansara ya m'chiberekero: Pochiza odwala 70 a khansa ya m'chiberekero, paclitaxel kuphatikizapo mankhwala a chemotherapy opangidwa ndi platinamu amachepetsa zotupa mu 76% ya odwala, ndipo kupulumuka kwa zaka ziwiri kunafika 38%.
4. Khansara ya m'mitsempha: Pochiza odwala 40 omwe ali ndi khansa ya m'mero, paclitaxel kuphatikiza ndi radiotherapy inachepetsa zotupa mwa 85% ya odwala, ndipo kupulumuka kwa chaka chimodzi kunafika 70%.
5. Khansa ya m'mimba: Pochiza khansa ya m'mimba, paclitaxel yophatikizidwa ndi fluorouracil imatha kusintha kwambiri kupulumuka kwa odwala.paclitaxelkuphatikizidwa ndi chemotherapy kunapangitsa moyo wapakatikati wa miyezi 15.
6. Khansara yamtundu: Pochiza odwala 30 a khansa yapakhungu, paclitaxel kuphatikiza ndi oxaliplatin idachepetsa zotupa mu 80% ya odwala, ndipo zaka ziwiri zomwe zidapulumuka zidafika 40%.
Khansara ya 7.Chiwindi: Ngakhale zotsatira za paclitaxel monotherapy pa khansa ya chiwindi ndizochepa, kuphatikiza mankhwala ena a chemotherapy monga cisplatin ndi 5-fluorouracil kungathandize kwambiri kupulumuka kwa odwala. ndi mankhwala amphamvu a chemotherapy anachititsa moyo wapakatikati wa miyezi 9.
8. Khansa ya Impso: Pochiza khansa ya impso, paclitaxel kuphatikiza ndi mankhwala oletsa chitetezo chathupi monga interferon-alpha angathandize kwambiri kuti odwala akhale ndi moyo. Miyezi 24.
9.Leukemia: Pochiza acute myeloid leukemia, paclitaxel kuphatikiza ndi mankhwala amphamvu monga cytarabine angapangitse odwala kuti akhululukidwe kwambiri. mu 80% ya odwala.
10, lymphoma: Pochiza matenda omwe si a Hodgkin lymphoma, paclitaxel kuphatikiza ndi mankhwala amphamvu monga cyclophosphamide amatha kuthandiza odwala kuti athe kuyankha bwino kwambiri. mu kuyankha kwathunthu mu 85% ya odwala.
Mapeto
Mwachidule, paclitaxel yasonyeza mphamvu zina pochiza mitundu yosiyanasiyana ya khansa. Kuvuta ndi kusiyana kwa khansa, ndondomeko za chithandizo ziyenera kusankhidwa payekha kwa wodwala aliyense.
Zindikirani: Zopindulitsa zomwe zingachitike ndikugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku osindikizidwa.
Nthawi yotumiza: Nov-17-2023