Njira Yopanga ndi Ukadaulo wa Paclitaxel API

Paclitaxel ndi mankhwala omwe amapezeka mwachilengedwe omwe ali ndi ntchito yayikulu yolimbana ndi khansa, yomwe imagwiritsidwa ntchito kwambiri pochiza makhansa osiyanasiyana.Paclitaxel APIamakhalanso akutukuka mosalekeza.Nkhaniyi ifotokoza za kupanga ndi luso la Paclitaxel API mwatsatanetsatane.

I.Source ndi Kutulutsa kwa Paclitaxel

Paclitaxel makamaka imachokera ku Taxus brevifolia, Taxus cuspidata, Taxus wallichiana ndi mitundu ina ya Taxus. Njira zochotsera zikuphatikizapo zosungunulira, zowonongeka za ultrasonic, microwave m'zigawo, etc.Solvent m'zigawo ndi njira yogwiritsidwa ntchito kwambiri, koma ili ndi mavuto monga nthawi yayitali yochotsa. ndi zosungunulira zazikulu zosungunulira.Chifukwa chake, m'zaka zaposachedwa, ochita kafukufuku akhala akuyesera njira zatsopano zochotsera, monga enzyme hydrolysis, supercritical fluid m'zigawo, etc., kuti apititse patsogolo kutulutsa bwino ndi chiyero.

II.Kupanga Njira ya Paclitaxel

Fermentation njira yopanga Paclitaxel

M'zaka zaposachedwa, njira zowotchera zaphunziridwa mozama popanga Paclitaxel. Njirayi imagwiritsa ntchito ukadaulo wa microbial fermentation kupanga Paclitaxel mwa kulima ndi kupesa ma cell a Taxus. Njirayi ili ndi maubwino monga kuzungulira kwaufupi, zokolola zambiri, komanso chiyero chambiri. , pamafunika kukhathamiritsa kwa mikhalidwe nayonso mphamvu ndikuyang'ana mitundu yokolola kwambiri kuti ipititse patsogolo kupanga bwino komanso kuchepetsa ndalama.

Chemical synthesis njira yopanga Paclitaxel

Kuphatikizika kwa mankhwala ndi njira ina yofunika kwambiri yopangira Paclitaxel.Njirayi imagwiritsa ntchito ukadaulo wa organic synthesis kuti ipangitse Paclitaxel kudzera munjira zopangira mankhwala. kukwera mtengo, zomwe zimachepetsa kugwiritsa ntchito kwake.

Kuphatikiza kwa m'zigawo zachilengedwe ndi kaphatikizidwe ka mankhwala pakupanga

Kuti athane ndi malire a njira imodzi yopanga, ofufuza akuwunikanso kuphatikiza kwachilengedwe komanso kaphatikizidwe ka mankhwala popanga.Njirayi imatulutsa zinthu zoyambira za Paclitaxel kuchokera ku mitundu ya Taxus pogwiritsa ntchito zosungunulira zosungunulira, kenako ndikuzisintha kukhala Paclitaxel pogwiritsa ntchito kaphatikizidwe ka mankhwala. Technology.This njira Chili ubwino m'zigawo zachilengedwe ndi kaphatikizidwe mankhwala, bwino kupanga dzuwa ndi chiyero, ndi kuchepetsa mtengo kupanga.

III.Challenges ndi Njira Zowonjezereka mu Paclitaxel Production Technology

Kupititsa patsogolo m'zigawo Mwachangu ndi chiyero: Kupanga njira imayenera ndi chilengedwe wochezeka m'zigawo ndi matekinoloje, monga solvents latsopano, michere gulu, etc., Kupititsa patsogolo m'zigawo Mwachangu ndi chiyero cha Paclitaxel.

Kukulitsa mikhalidwe nayonso mphamvu ndi kuyeza mitundu yololera kwambiri: Kuwongolera mikhalidwe ya nayonso mphamvu (monga kapangidwe ka sing'anga, kutentha, pH mtengo, etc.) ndikuyang'ana mitundu yololera kwambiri kuti muwonjezere zokolola komanso chiyero cha kupanga kwa Paclitaxel.

Kuchepetsa ndalama zopangira: Kupanga zida zatsopano, kukonza njira zopangira, komanso kukwaniritsa kupanga kwakukulu kuti muchepetse mtengo wopangira Paclitaxel ndikuwongolera mpikisano wamsika.

Kulimbikitsa kuwongolera khalidwe: Kukhazikitsa dongosolo lonse lowongolera khalidwe kuti liziwongolera bwino zinthu zopangira, njira zopangira, ndi zogulitsa kudzera muulamuliro wokhazikika wa khalidwe ndi kuyesa kuyesa kuonetsetsa kuti katundu ndi chitetezo.

Kupanga mapangidwe atsopano: Kupanga mapangidwe atsopano (monga nanomatadium, ma liposome formulations, ndi zina) kuti apititse patsogolo bioavailability ndi mphamvu ya Paclitaxel mu vivo kutengera zovuta zake zamankhwala.

Kukulitsa magawo ogwiritsira ntchito: Kukulitsanso magawo ogwiritsira ntchito Paclitaxel kupitilira chithandizo cha khansa (monga anti-yotupa, antioxidant zotsatira), kuti awonetse zotsatira zake zamankhwala komanso kufunika kwake.

IV.Mapeto ndi Zoyembekeza

Ndi kupita patsogolo kosalekeza kwa sayansi ndi ukadaulo komanso kuchuluka kwa kufunikira kwachipatala kwaPaclitaxel APIM'tsogolomu, ofufuza apitiliza kufufuza njira zatsopano zopangira ndi luso lothandizira kupanga Paclitaxel, kuchepetsa ndalama zopangira, kukulitsa minda yake, ndikupanga zopereka zambiri. ku thanzi la munthu.

Zindikirani: Mphamvu zomwe zatchulidwa m'nkhaniyi zimachokera m'mabuku ofalitsidwa ndi anthu.