Paclitaxel, Mankhwala oletsa khansa ochokera ku Taxus chinensis

Paclitaxel ndi mankhwala otengedwa ku yew, omwe amatha kuletsa khansa ndipo ndi mankhwala omwe amagwiritsidwa ntchito kwambiri padziko lonse lapansi. Kafukufuku wachipatala, jakisoni woyamba wa paclitaxel "Taxol" adakhazikitsidwa mu 1992.paclitaxelNdi imodzi mwamankhwala odziwika bwino a botanical anti-chotupa omwe ali ndi mphamvu yabwino. Ili ndi mawonekedwe achangu, kawopsedwe kakang'ono komanso mawonekedwe otakasuka. Ili ndi zotsatira zodziwikiratu zochizira khansa ya ovarian, khansa ya m'mawere, khansa yoyipa ya melanoma, khansa ya m'mapapo, khansa ya prostate, ubongo. khansara ndi khansa yapakhungu.

Zotsatira za kuyesa kwachipatala zikuwonetsa kuti, pakali pano, kupeza kwapaclitaxel APIsmakamaka zimadalira m'zigawo za Taxus chinensis zomera ndi mankhwala Semisynthesis.Ofufuza sayansi kusonkhanitsa yokumba nakulitsa nthambi ndi masamba a Taxus chinensis chinensis, ntchito zosungunulira m'zigawo, olimba gawo m'zigawo, Supercritical madzimadzi m'zigawo, kupatukana kwa membrane, kupatukana kwa chromatographic ndi njira zina zopatukana ndi m'zigawo. Tulutsani ma precursors ofanana ndi kapangidwe ka paclitaxel, monga bacatine III,10 deacetyl bacatine III, etc.,ndipo kenaka pezani mankhwala ochulukirapo a paclitaxel posintha njira zopangira misa.

Malinga ndi mawerengedwe a asayansi, odwala khansa ayenera kudya zoposa 2 magalamu apaclitaxelMankhwalawa amayenera kuchotsedwa ku khungwa la mitengo ya Taxus chinensis 4-8 yomwe yakula kwa zaka zoposa 50. Kumbali imodzi, Taxus chinensis ndi paclitaxel ndizosowa, ndipo Kumbali ina, pali kufunikira kwakukulu kwachipatala, komwe kumatsogolera kumtengo wokwera wa zida za Taxus chinensis chaka chonse, ndipo kupezeka sikukwanira.

Kufotokozera: Mphamvu zomwe zingagwiritsidwe ntchito ndi zomwe zatchulidwa m'nkhaniyi zonse zachokera m'mabuku opezeka pagulu.

Kuwerenga kowonjezereka:Yunnan Hande Bio-tech imagwira ntchito yochotsa ndi kupanga taxanes.Zogulitsa zake zazikulu ndi Paclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel,etc.Ngati mukufuna kudziwa za paclitaxel based zopangira, chonde omasuka kulankhula nafe pa.