Natural Paclitaxel VS Semi-synthetic Paclitaxel(II)

Yew taxus chinensis Tingafinye amachokera ku zomera zachilengedwe kusowa, anaika, tsinde, khungu, muzu muli zosakaniza zazikulu ndi: yew alkali diterpenoid mankhwala, yew ning A ndi yew, yew ning H, yew, yew ning K,l,yew alkali, jinsong yellow ketone, otsetsereka amene amachoka A, this leave ketone ketone, jinsong double yellow ketone,naphtha,yew,polysaccharide,tannins,tanned red, etc.,thanso kukhala ndi ma polyphenols,amino acid,utomoni wa nkhuni,zinthu zina.Paclitaxel ili anti-leukemia ndi chotupa zotsatira.

Paclitaxel, yomwe tikambirana, ndi mankhwala abwino kwambiri oletsa khansa omwe apezeka mpaka pano. Amagwiritsidwa ntchito kwambiri pochiza khansa ya m'mawere, khansa ya m'mawere, khansa ya mutu ndi khosi, khansa ya m'mapapo ndi zina zambiri. khansa zina zachipatala.

Natural Paclitaxel vs Semi-synthetic Paclitaxel

Zoyipa:

Natural paclitaxelamachotsedwa ku mizu, zimayambira ndi masamba a Taxus chinensis.After column chromatography and recrystallization, the whole process is physical m'zigawo ndi kuyeretsedwa popanda chemical reaction.Zonyansa zomwe zili mmenemo zimachokera ku zosakaniza za zomera zokha, ndipo palibe zonyansa. zobweretsedwa ndi mankhwala synthesis.Choncho, kukonza zonyansa za paclitaxel zachilengedwe zimaphunziridwa mokwanira komanso kulamuliridwa pakali pano.

Semisynthetic paclitaxelali ndi kaphatikizidwe ka mankhwala ochulukirapo kuposa achilengedwe m'njira yake, ndipo zonyansa zake zimakhalanso zochulukirapo kuposa zachilengedwe, kuphatikiza zina zotengedwa muzomera, ndi zonyansa zina zopangidwa ndi chemical synthesis reaction. Munjira iyi, kuchuluka ndi mtundu wa zonyansa zimasintha nthawi zonse.Chifukwa chake, semi-synthetic paclitaxel imakhala ndi kuwongolera kochepa mu zonyansa, ndipo zonyansa zatsopano ziyenera kuphunziridwa mosalekeza popanga. Zowonongeka zomwe zimapangidwa ndi njira zosiyanasiyana zopangira zimapangidwiranso. zosiyana kwambiri, ndipo kusanthula kwapadera kumafunika.

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