Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

Chipangizo Mankhwala

Paclitaxel, monga mankhwala oletsa khansa, amagwiritsidwa ntchito kwambiri mu jakisoni ndi zida zosiyanasiyana.

Zimapangidwa makamaka ndi kutulutsa kwachilengedwe ndi kaphatikizidwe.

Monga gwero la chomera cha paclitaxel chotengedwa mwachilengedwe, Taxus Chinensis, ndi chosowa ndipo chimakhala ndi kukula kwanthawi yayitali, njira zingapo zophatikizira zatengedwa pang'onopang'ono kuchokera ku paclitaxel kudzera mu kafukufuku ndi zoyeserera padziko lonse lapansi, kuphatikiza kaphatikizidwe kokwanira, semi-synthesis, ndi endophytic kaphatikizidwe.

Chifukwa cha njira yayitali yophatikizira mankhwala, masitepe ambiri ophatikizika, komanso zovuta kuwongolera momwe zinthu zimachitikira, paclitaxel yopangidwa bwino iyenera kugwiritsa ntchito ma reagents okwera mtengo kwambiri, ndipo zokolola zimakhalanso zotsika, zomwe sizoyenera kupanga misa ndi kupanga mafakitale. wamba.

Chifukwa chake, kuchuluka kwa paclitaxel pamsika nthawi zambiri kumapangidwa ndi kutulutsa kwachilengedwe kwa taxus yolimidwa ndi njira zopangira semi-synthetic.

Natural Paclitaxel vs Semi-synthetic Paclitaxel

Gawo 1: Njira Yopangira

Natural paclitaxel:

- Zopangira: Yew yobzalidwa mwachisawawa

-Njira yochotsa: zopangira+kholamu chromatography+recrystallization = mankhwala omalizidwa

- M'zigawo ndondomeko: thupi anachita, palibe ndondomeko synthesis mankhwala

Semisynthetic Paclitaxel:

- Zopangira: Yew yobzalidwa mwachisawawa

-Njira yochotsera: zopangira+mankhwala reagent reaction+incentrated crystallization+mitundu yosiyanasiyana yamankhwala+recrystallization = kumaliza mankhwala

- M'zigawo ndondomeko: mankhwala anachita

Pankhani yaukadaulo, paclitaxel yachilengedwe imakhala ndi masitepe osavuta otulutsa poyerekeza ndi semi-synthetic paclitaxel komanso zabwino zambiri kuposa semi-synthetic paclitaxel pankhani yokhazikika komanso chitetezo, pomwe semi-synthetic paclitaxel imachepetsa mtengo wopangira zinthu potengera mtengo ndi zopangira. , komanso kukonza mavuto ena obwera chifukwa cha kusowa kwa zinthu zopangira pamsika.

Poyerekeza ndi njira ziwiri zopangira paclitaxel, paclitaxel yachilengedwe imakhala yokhazikika komanso yotetezeka pazida zamankhwala, chomwe ndi chifukwa chimodzi chomwe makampani ambiri azachipatala pamsika amagwiritsira ntchito paclitaxel ngati zopangira.

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