Natural paclitaxel: mankhwala othandiza kwambiri komanso otsika poizoni oletsa khansa

Paclitaxel, mankhwala achilengedwe oletsa khansa omwe ali ndi formula C47H51NO14, amagwiritsidwa ntchito kwambiri pochiza khansa ya m'mawere, khansa ya m'mawere ndi khansa ya mutu, khosi ndi m'mapapo.Monga diterpenoid alkaloid ndi anticancer ntchito,paclitaxeladayamikiridwa kwambiri ndi akatswiri a zamankhwala, akatswiri a zamankhwala, azamankhwala ndi akatswiri a sayansi ya mamolekyulu chifukwa cha buku lake komanso kapangidwe kake kake kake kovutirapo, ntchito yayikulu komanso yofunika kwambiri yachilengedwe, njira zatsopano komanso zapadera zogwirira ntchito, komanso kuchepa kwa zinthu zachilengedwe, zomwe zimapangitsa kuti ikhale nyenyezi komanso chidwi chofufuza za anticancer. theka lachiwiri la zaka za zana la 20.

Njira yamachitidwe a paclitaxel

Paclitaxel imalepheretsa kuchuluka kwa maselo a khansa makamaka poyambitsa kumangidwa kwa ma cell ndikuyambitsa tsoka la mitotic.Kapangidwe kake kakang'ono komanso kapangidwe kake kake kake kamapangitsa kuti pakhale njira yapadera yochitira zinthu.Paclitaxelimatha kuletsa kuchuluka kwa maselo poletsa polymerization ya tubulin ndikuwononga ma cell a microtubule network.Kuphatikiza apo, paclitaxel imathanso kuwonetsa oyimira pakati pa pro-apoptotic ndikuwongolera zochitika za anti-apoptotic mediators, potero kupangitsa kuti ma cell a khansa apangidwe.

Ntchito yolimbana ndi khansa ya paclitaxel

Paclitaxel yakopa chidwi kwambiri chifukwa chakuchita bwino kwambiri komanso kuchepa kwa kawopsedwe ka anticancer.Pazachipatala, paclitaxel yasonyezedwa kuti ili ndi zotsatira zochiritsira pamitundu yosiyanasiyana ya khansa, kuphatikizapo khansa ya m'mawere, khansa ya ovarian, khansa ya mutu ndi khosi, ndi khansa ya m'mapapo.Kudzera mu njira yake yapadera yachilengedwe, paclitaxel imatha kuletsa kuchuluka kwa maselo a khansa ndikupangitsa kuti ma cell a khansa apangidwe.Kuphatikiza apo, ntchito yolimbana ndi khansa ya paclitaxel imagwirizananso ndi kuthekera kwake kuwongolera chitetezo chamthupi cha maselo otupa.

Kuchepa kwazinthu za paclitaxel

Ngakhale paclitaxel ili ndi ntchito yayikulu yolimbana ndi khansa, kusowa kwake kwazinthu kumalepheretsa kugwiritsidwa ntchito kwake kwachipatala.Paclitaxel imachokera kumitengo ya Pacific yew, ndipo chifukwa cha kuchepa kwachilengedwe, kupanga paclitaxel sikukwaniritsa zosowa zachipatala.Chifukwa chake, kusaka magwero atsopano a paclitaxel, monga kupanga paclitaxel ndi biosynthesis kapena chemical synthesis, ndiye cholinga cha kafukufuku wamakono.

mapeto

Monga mankhwala achilengedwe oletsa khansa,paclitaxelali ndi mawonekedwe achangu kwambiri, kawopsedwe wochepa komanso mawonekedwe otakata, ndipo njira yake yapadera yachilengedwe yochitira zinthu komanso ntchito yayikulu yolimbana ndi khansa imapangitsa kuti ikhale yofunika kwambiri pochiza khansa pazachipatala.Komabe, chifukwa cha kuchepa kwa zinthu zake, kugwiritsidwa ntchito kwake kwakukulu muzochitika zachipatala kumakhala kochepa.Choncho, kafukufuku wamtsogolo ayenera kuyang'ana pa kupeza magwero atsopano a paclitaxel kuti akwaniritse zosowa zachipatala ndikupereka njira zambiri zothandizira odwala khansa.

Zindikirani: Mapindu omwe angakhalepo komanso momwe angagwiritsire ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku ofalitsidwa.