Paclitaxel ndi mankhwala achilengedwe otengedwa ku Taxus, omwe amagwira ntchito pa tubulin kuti alepheretse mitosis ya maselo otupa.Pakali pano, paclitaxel ndiye mankhwala abwino kwambiri othana ndi khansa omwe apezeka. Kuchita bwino kwachipatala pochiza khansa ya m'mawere, khansa ya m'mawere, khansara ya m'mapapo yosakhala yaying'ono, khansa ya m'mapapo ndi zotupa zina.
Chifukwa paclitaxel yachikhalidwe imakhala ndi lipophilic kwambiri, ndipo chogwiritsira ntchito chimakhala chovuta kusungunuka m'madzi, ethanol ya anhydrous, polyoxyethylene castor oil, etc. amagwiritsidwa ntchito pokonzekera kuti athetse kusungunuka. ndipo pazovuta kwambiri, kugwedezeka kwa anaphylactic kumatha kuchitika, kuyika moyo pachiswe. Chiwerengero cha ziwengo ndi chokwera mpaka 20% -40%. Kuti mutetezedwe mogwira mtima, chithandizo chamankhwala ndi corticosteroids ndi antihistamines chiyenera kuchitidwa musanalowe. Paclitaxel iyenera kuchepetsedwa mu zambiri musanayambe jekeseni mtsempha, ndipo nthawi kulowetsedwa ayenera kukhala osachepera 3 hours.
Pofuna kuthana ndi vutoli, paclitaxel yokhala ndi albumin bound paclitaxel imaphatikiza hydrophobic paclitaxel ndi albumin kupanga nanoparticles ndi kukula kwa pafupifupi 130 nm pogwiritsa ntchito nanotechnology yapadera. Imagwiritsa ntchito njira yapadera yoyendera zachilengedwe albumin imapangitsa kuti paclitaxel igawidwe kwambiri m'matenda a chotupa ndikufikira kuchuluka kwambiri m'ma cell chotupa; Imapewa kugwiritsa ntchito ethanol ya anhydrous, polyoxyethylene castor oil ndi zosungunulira zina, imachepetsa kwambiri kuyambika kwa matupi awo sagwirizana, ndipo safuna anti matupi awo sagwirizana pretreatment musanagwiritse ntchito. ,ndipo safuna kugwiritsa ntchito kulowetsedwa kwapadera device.The kulowetsedwa akhoza anamaliza mu theka la ola.Imakwaniritsadi mkulu machiritso zotsatira ndi otsika kawopsedwe.
Zindikirani: Kuthekera komanso kugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zonse zachokera m'mabuku osindikizidwa.
Yunnan Hande Biotechnology Co., Ltd yakhala ikugwira ntchito yopangapaclitaxel APIkwa zaka zoposa 20, ndipo ndi mmodzi mwa opanga okha padziko lonse lapansi a paclitaxel API, mankhwala odana ndi khansa omwe amachokera ku zomera, ovomerezedwa ndi US FDA, European EDQM, TGA yaku Australia, Chinese CFDA, India, Japan ndi mabungwe ena olamulira dziko. .Hande ikhoza kupereka osati zapamwamba zokhapaclitaxel zopangira,komanso ntchito zokweza zaukadaulo zokhudzana ndi paclitaxel formulation.Kuti mumve zambiri, chonde omasuka kulankhula nafe pa 18187887160.
Nthawi yotumiza: Dec-21-2022