Chifukwa cha kuthamanga kwa magazi, kuthamanga kwambiri komanso kuthamanga kwa malo okhala, anthu ena nthawi zambiri amachedwetsa kugona usiku, zomwe zimapangitsa kuti agone, zomwe zimachititsa kuti asagone. Titani? kukhala njira yothetsera vutoli.
Panthawi yomwe anthu ambiri akumvamelatonin, iwo amaganiza kuti melatonin ndi chinthu chokongola. Ndipotu, melatonin ndi hormone yamkati yomwe imapangitsa kugona kwachilengedwe. Imagonjetsa zopinga za kugona komanso imapangitsa kugona bwino poyendetsa kugona kwachilengedwe kwa anthu. kuthandiza kugona.
Malinga ndi ziwerengero za bungwe la World Health Organisation, chiwerengero cha matenda ogona padziko lonse ndi 27%, chomwe chakhala chachiwiri kwa anthu ambiri padziko lonse lapansi. Lipoti lomwe linatulutsidwa ndi bungwe lofufuza za kugona ku China likusonyeza kuti anthu oposa 300 miliyoni ku China ali ndi vuto la kugona, pamene chiwerengero cha kusowa tulo kwa akuluakulu ndi 38.2%.
Ndiye kodi Melatonin ingathandizedi kugona?
###Tiyeni tiwone melatonin ndi ntchito yake.
Melatonin(MT) ndi imodzi mwa mahomoni opangidwa ndi pineal gland.Melatonin ndi ya indole heterocyclic compounds.Dzina lake la mankhwala ndi N-acetyl-5 methoxytryptamine, yomwe imadziwikanso kuti pinealoxin.After melatonin synthesis, imasungidwa mu pineal gland. Kusangalatsa kwachifundo kumapangitsa kuti maselo a pineal gland atulutse melatonin. Katulutsidwe ka melatonin kamakhala ndi kamvekedwe kake ka circadian, kamene kamalepheretsa masana komanso usiku.
Melatonin imatha kulepheretsa hypothalamic pituitary gonadal axis, kuchepetsa zomwe zili mu gonadotropin kutulutsa timadzi, gonadotropin, luteinizing hormone ndi follicular estrogen, komanso kuchitapo kanthu pa gonads kuchepetsa zomwe zili mu androgen, estrogen ndi progesterone. Kafukufuku waposachedwa akuwonetsa kuti melatonin ndi Mtsogoleri wamkulu wa endocrine. Imayendetsa ntchito za ma endocrine glands osiyanasiyana m'thupi, motero amalamulira mosadziwika bwino ntchito ya thupi lathu lonse.
Ntchito ndi Kuwongolera kwa Melatonin
1) Sinthani kayimbidwe ka circadian
Kutulutsa melatonin kuchokera kunja kwa thupi kumatha kusunga mlingo wa melatonin m'thupi mudakali wamng'ono, kusintha ndi kubwezeretsanso kayimbidwe ka circadian, osati kungowonjezera tulo komanso kugona bwino, komanso kumapangitsa kuti thupi likhale labwino. thupi lonse, kumapangitsa moyo kukhala wabwino komanso kuchedwetsa kukalamba. Chifukwa ndi kukula kwa ukalamba, pineal gland imachepa mpaka calcification, zomwe zimachititsa kufooka kapena kuzimiririka kwa rhythm ya biological clock. Makamaka pambuyo pa zaka 35; melatonin yotulutsidwa ndi thupi imachepa kwambiri, ndi kuchepa kwapakati pa 10 ~ 15% zaka 10 zilizonse, zomwe zimachititsa kuti munthu asagone komanso asamagwire bwino ntchito. kukalamba.
2)Kuchedwa kukalamba
The pineal gland ya okalamba imachepa pang'onopang'ono, ndipo kutulutsa kwa MT kumachepa moyenerera.Kuchuluka kwa Mel komwe kumafunidwa ndi ziwalo zosiyanasiyana m'thupi sikukwanira, kumayambitsa ukalamba ndi matenda.Asayansi amatcha pineal gland nthawi yokalamba ya thupi.Tikawonjezera MT kuchokera kunja, titha kubweza wotchi yokalamba.
3) Pewani zotupa
Chifukwa MT imatha kulowa m'maselo mosavuta, ingagwiritsidwe ntchito kuteteza DNA ya nyukiliya.Ngati DNA yawonongeka, ikhoza kuyambitsa khansa.Ngati pali Mel wokwanira m'magazi, sizovuta kupeza khansa.
4) Zowongolera pamayendedwe apakati amanjenje
Kafukufuku wambiri wazachipatala komanso woyesera akuwonetsa kuti melatonin, monga mahomoni amtundu wa neuroendocrine, ali ndi malamulo olunjika komanso osadziwika bwino pamayendedwe apakati a minyewa, machiritso okhudza kugona, kukhumudwa ndi matenda amisala, komanso chitetezo pama cell a mitsempha. , melatonin imakhala ndi sedative effect, imathanso kuchiza kuvutika maganizo ndi psychosis, imatha kuteteza mitsempha, imatha kuthetsa ululu, kuyendetsa mahomoni otulutsidwa ndi hypothalamus ndi zina zotero.
5) Kuwongolera chitetezo cha mthupi
Zaka khumi zaposachedwa, kuwongolera kwa melatonin pachitetezo cha chitetezo chamthupi kwakopa chidwi chofala. Kafukufuku wakunyumba ndi kunja awonetsa kuti melatonin imakhudza kukula ndi kukula kwa ziwalo zoteteza thupi, komanso imayendetsa chitetezo chamthupi, chitetezo cham'manja ndi ma cytokines. Mwachitsanzo, melatonin imatha kuwongolera chitetezo cham'manja ndi humoral, komanso ntchito zamitundu yosiyanasiyana ya ma cytokines.
6) Kuwongolera magwiridwe antchito amtima
Ntchito ya mitsempha ya mitsempha imakhala ndi kamvekedwe ka circadian ndi kamvekedwe ka nyengo, kuphatikizapo kuthamanga kwa magazi, kugunda kwa mtima, kutulutsa mtima, renin angiotensin aldosterone, ndi zina zotero. .Kuonjezera apo, zotsatira zoyenera zoyesera zinatsimikizira kuti kuwonjezeka kwa MT secretion usiku kunali kogwirizana kwambiri ndi kuchepa kwa ntchito ya mtima; Pineal melatonin imatha kuteteza arrhythmia chifukwa cha kuvulala kwa ischemia-reperfusion, kumakhudza kulamulira kwa magazi, kuyendetsa magazi a ubongo, ndi kuwongolera reactivity kwa zotumphukira mitsempha kuti norepinephrine.
7) Kuphatikiza apo, melatonin imayang'aniranso dongosolo la kupuma kwamunthu, m'mimba komanso mkodzo.
Malangizo kwa Melatonin
melatoninSi mankhwala.Amatha kukhala ndi gawo lothandizira pakusok munthawi yake ndikupeza chithandizo choyenera chamankhwala.
Mukufuna kudziwa zambiri za melatonin?Hande yadzipereka kupatsa makasitomala zinthu zotulutsa bwino komanso zathanzi.Timapereka mankhwala a melatonin apamwamba komanso apamwamba kwambiri kuti akuthandizeni kugona bwino komanso kukhala ndi moyo wabwino tsiku lililonse!
Nthawi yotumiza: May-11-2022