Zambiri Zamalonda
Tsamba la mabulosi DNJ ndi alkaloid yachilengedwe, yomwe dzina lake lachi China ndi 1-deoxynojirimycin.Ndi mphamvu yamphamvu ya glucose metabolizing enzyme (mwachitsanzo, α- Glycosidase) inhibitor imatha kuchedwetsa kwambiri kuwonongeka kwa polysaccharide, kuchepetsa kuchuluka kwa shuga m'magazi a postpandial ndikukhazikitsa shuga wamagazi osala kudya;Ndi ya "inhibitory factor" pakati pa zinthu zinayi zowongolera shuga za alfa.
1, Zotsatira za tsamba la mabulosi DNJ
1. Njira zitatu zochepetsera shuga m'magazi
Monga choletsa champhamvu cha michere ya shuga metabolizing (monga α-Glucosidase, hexokinase, glucuronidase ndi glycogen phosphatase, ndi zina zotero), DNJ imatha kuchedwetsa kwambiri kuwonongeka kwa polysaccharide, kuchepetsa kuchuluka kwa shuga m'magazi a postprandial ndikukhazikitsa shuga wamagazi osala kudya.Kuphatikiza apo, DNJ imakhala ndi mphamvu yolimbikitsa insulin kuti ipititse patsogolo kukana kwa insulin.
2. Chepetsani shuga wamagazi pambuyo pakudya.
α- Glucosidase imagawidwa makamaka m'matumbo aang'ono a munthu ndipo imagwira ntchito yofunika kwambiri pakuwonongeka kwa chakudya.Iwo ali ndi udindo wa kuwonongeka kwa oligosaccharides monga oligosaccharides mu chakudya kukhala monosaccharides, monga shuga.Glucose uyu amalowa m'thupi kudzera m'khoma la matumbo, zomwe zimayambitsa kukwera kwambiri kwa glycemia.DNJ ndi yachilengedwe komanso yamphamvu α-Glucosidase inhibitors yomwe imamangiriza mopikisana m'matumbo ang'onoang'ono α- Kugwirizana kwa glucosidase ndikwapamwamba kuposa oligosaccharides monga sucrose ndi maltose α-Glucosidase ali ndi mgwirizano wamphamvu komanso amachepetsa oligosaccharides ndi α-glucosidase. , kuti aletse kuwonongeka kwa fructose kukhala shuga, ndipo kuchuluka kwa shuga sikungatengedwe ndikutumizidwa kumatumbo akulu.Chifukwa cha mphamvu ya DNJ, shuga wocheperako amalowa m'magazi, motero shuga wamagazi ndi wofunika kukhalabe wathanzi.
3. Kusala kudya shuga wamagazi.
DNJ ili ndi ntchito yoletsa ya glycogen phosphorylase, yomwe imatha kuchedwetsa kuwonongeka kwa chiwindi cha glycogen kukhala shuga, kuti akhazikitse shuga wamagazi osala kudya.Glucose "wowonjezera" m'thupi la munthu amasungidwa m'chiwindi monga glycogen.Glycogen imatha kuthyoledwa kukhala shuga pansi pa zochita za glycogen phosphorylase ndikutulutsidwa m'magazi kuti ikwaniritse zosowa za minofu ndi ziwalo zina.Glycogen ndi imodzi mwazinthu zazikulu zopangira mphamvu zolimbitsa thupi.Ndi kusintha kwapakati pakati pa glycogen ndi shuga, shuga m'magazi mwa anthu abwinobwino amakhala okhazikika.Odwala omwe ali ndi matenda a shuga, chifukwa cha kusokonekera kwa kagayidwe ka glucose, glycogen wochulukirapo amagawika kukhala shuga, zomwe zimapangitsa kuti shuga achuluke m'magazi osala kudya.DNJ imatha kulepheretsa kugwira ntchito kwa glycogen phosphorylase ndikuletsa kuchuluka kwa shuga m'magazi chifukwa cha kuwonongeka kwa glycogen kukhala shuga, kuti akhazikitse shuga wamagazi osala kudya.
4. Sinthani kukana insulini.
DNJ imatha kusintha zizindikiro za insulin kukana mwa kukonza kagayidwe ka lipid, kuchepetsa kaphatikizidwe ka shuga ndi kukhudzidwa kwa insulin.Kukana kwa insulin kumatanthawuza zifukwa zosiyanasiyana (makamaka kuphatikiza ma genetic ndi kunenepa kwambiri), zomwe zimachepetsa mphamvu ya insulin yomwe imalimbikitsa kuyamwa ndi kugwiritsidwa ntchito kwa shuga, ndipo thupi limatulutsa insulini yochulukirapo.Kukana insulini kumapanga hyperinsulinemia kuti asunge kukhazikika kwa shuga m'magazi.Ngati thupi la munthu limakhala losagwirizana ndi insulin kwa nthawi yayitali, zimachulukitsa kwambiri kapamba.Zitha kupangitsa kuti kapamba atulutse kulephera kwa insulini ndipo kenako kukhala shuga.DNJ imatha kusintha zizindikiro za insulin kukana mwa kukhalabe ndi shuga wabwino m'magazi, kukonza kagayidwe ka lipid ndikuwonjezera chidwi cha insulin.
2, Ntchito minda ya mabulosi tsamba DNJ
Mabulosi a mabulosi a masamba a mabulosi a DNJ amalembedwa ngati othandizira a hypoglycemic ndipo amagwiritsidwa ntchito kwambiri pazakudya zathanzi.
Product Parameters
| MBIRI YAKAMPANI | |
| Dzina lazogulitsa | Tsamba la Mabulosi DNJ |
| CAS | 19130-96-2 |
| Chemical Formula | C6H13NO4 |
| Brandi | Hndi |
| Mwopanga | YMalingaliro a kampani unnan Hande Bio-Tech Co., Ltd. |
| Ckunja | Kunming,Cine |
| Kukhazikitsidwa | 1993 |
| BMALANGIZO ASIC | |
| Mawu ofanana ndi mawu | (2r, 3r, 4r, 5s) -2-hydroxymethyl-3,4,5-trihydroxypiperidine;5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4;bay-h5595;moranolin;moranoline; (+)-1-DEOXYNOJIRIMYCIN;1-DEOXYNOJIRIMYCIN;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL |
| Kapangidwe |  |
| Kulemera | N / A |
| HS kodi | N / A |
| UbwinoStanthauzo | Mafotokozedwe a Kampani |
| Czotsimikizira | N / A |
| Kuyesa | Zosinthidwa malinga ndi zosowa za makasitomala |
| Maonekedwe | White ufa |
| Njira Yochotsera | Yotengedwa mabulosi masamba ndi muzu khungwa |
| Kutha Kwapachaka | Zosinthidwa malinga ndi zosowa za makasitomala |
| Phukusi | Zosinthidwa malinga ndi zosowa za makasitomala |
| Njira Yoyesera | Mtengo wa HPLC |
| Kayendesedwe | Zambiritransports |
| PayimentTerms | T/T, D/P, D/A |
| Oawo | Landirani kuwunika kwamakasitomala nthawi zonse;Thandizani makasitomala polembetsa zowongolera. |
Hande product statement
1.Zogulitsa zonse zomwe zimagulitsidwa ndi kampaniyo ndi zopangira zomaliza.Zogulitsazo zimayang'ana makamaka kwa opanga omwe ali ndi ziyeneretso zopanga, ndipo zopangira sizinthu zomaliza.
2.Kuthekera kothekera ndi ntchito zomwe zikuphatikizidwa m'mawu oyamba onse amachokera m'mabuku osindikizidwa.Anthu samalimbikitsa kugwiritsa ntchito mwachindunji, ndipo kugula payekha kumakanidwa.
3. Zithunzi ndi zambiri zazinthu zomwe zili patsamba lino ndizongongotchula zokhazokha, ndipo zomwe zili zenizeni ndizoyenera.
