Vumbulutsani ulendo wovuta wa paclitaxel: kuchokera kuzinthu zachilengedwe kupita kuzinthu zopanga

Paclitaxel ndi mankhwala achilengedwe omwe adatengedwa kuchokera ku khungwa la mtengo wa Pacific yew (Taxus pacifica) . zovuta pakupanga mafakitale enieni.Nayi chithunzithunzi chonse cha paclitaxel biosynthesis:

1.Zinthu zoyambira: The biosynthesis ya paclitaxel imayamba ndi zinthu zoyambira zachilengedwe, nthawi zambiri kuchokera masamba kapena khungwa la mtengo wa yew.Zida zoyambirazi zili ndi mankhwala a makolo omwe angagwiritsidwe ntchito popanga zoyambira za paclitaxel.

2.Multi-enzyme catalysis:Biosynthesis yapaclitaxelPamafunika ma enzyme angapo kuti apangitse zomwe zimachitika.Ma enzymes awa amasintha zomwe zimayambira kukhala zapakati zomwe pang'onopang'ono zimapanga ma molekyulu a paclitaxel.

3.Synthesis of intermediates: Intermediates ndi sitepe yofunika kwambiri pa kaphatikizidwe ka paclitaxel.Izo zimakhala ndi ma polycyclic mankhwala ndi ma chain chain particles omwe amapangidwa pang'onopang'ono kupyolera muzotsatira za enzyme-catalyzed.

4.Final synthesis ya paclitaxel:Mamolekyu oyambilira a kaphatikizidwe ka paclitaxel amapangidwa pang'onopang'ono kukhala mamolekyu a paclitaxel m'njira zingapo.

5.Kutulutsa ndi kuyeretsedwa: Pambuyo pa kaphatikizidwe ka paclitaxel, sitepe yochotsa ndi kuyeretsa imafunika kupatutsa paclitaxel yoyera kusakaniza.

Ngakhale zachilengedwe biosynthetic njira zapaclitaxelaphunziridwa, kupanga kwenikweni kwa paclitaxel kumakhalabe kovuta chifukwa kumafuna kaphatikizidwe kovutirapo ndi masitepe angapo komanso kuchuluka kwa zinthu zopangira. kaphatikizidwe ka paclitaxel nthawi zambiri kumaphatikizapo njira yophweka yochepetsera zovuta.

Zindikirani: Zopindulitsa zomwe zingachitike ndikugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku osindikizidwa.

Yunnan Hande Biotechnology Co., Ltd. yakhala ikuyang'ana kwambiri pakupanga paclitaxel kwa zaka 26, ndipo ndi wopanga palokha wa mankhwala odana ndi khansa a paclitaxel API ovomerezedwa ndi United States FDA, European EDQM, Australia TGA, China CFDA , India, Japan ndi mabungwe ena olamulira dziko.Yunnan Hande paclitaxel, malo ogulitsa, fakitale mwachindunji malonda, talandiridwa kufunsa, 18187887160 (WhatsApp nambala yomweyo)