Njira yopangira Paclitaxel, mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza khansa, ndizovuta komanso zovuta kwambiri zomwe zimakhudza masitepe angapo, kuchokera kuzinthu zachilengedwe kupita ku mankhwala omaliza a mankhwala.Pepalali lifotokoza njira yopangirapaclitaxel, kuchokera m'zigawo mpaka kukonzekera.
Gawo 1: Chotsani
Paclitaxeladachotsedwa ku khungwa la mtengo wa Pacific yew, Taxus pacifica.Njirayi imayamba ndi kusonkhanitsa makungwa ndipo nthawi zambiri imafunika kusamala mosamala kuti musawononge mtengo.Khungwa losonkhanitsidwalo limathyoledwa ndi kuikidwa mu chosungunulira choyenera, monga etha kapena xylene.Paclitaxel imasungunuka kuchokera ku khungwa kukhala chosungunulira mu sitepe iyi kuti ipange chotsitsa.
Gawo 2: Kulekana
Zotulutsa nthawi zambiri zimakhala ndi mitundu yosiyanasiyana, kotero paclitaxel imayenera kupatulidwa ndi zinthu zina.Sitepe iyi nthawi zambiri imagwiritsa ntchito chromatographic chromatography kapena njira zina zolekanitsa kuti alekanitse paclitaxel ndi zinthu zina kutengera momwe zinthu ziliri.
Gawo 3: Kuyeretsedwa
Paclitaxel yopatulidwa iyenera kuyeretsedwanso kuti ichotse zonyansa zonse ndikupeza chinthu choyera kwambiri.Izi zimaphatikizapo masitepe monga crystallization, kusefera, ndi recrystallization kuonetsetsa kuti paclitaxel yomaliza ndi yoyera kwambiri.
Gawo 4: kaphatikizidwe (posankha)
Ngakhale kuti paclitaxel yoyambirira idachotsedwa kuzinthu zachilengedwe, makampani angapo opanga mankhwala apanga njira zopangira.Njirazi zimagwiritsa ntchito njira zopangira mankhwala kuti ziwonjezeke zokolola ndikuwongolera ndikuchepetsa kudalira zachilengedwe.
Khwerero 5: Konzani mankhwalawa
Gawo lomaliza pakupanga ndikukonzekera paclitaxel yoyeretsedwa pokonzekera kugwiritsidwa ntchito kwachipatala.Izi zingaphatikizepo kusungunula paclitaxel mu zosungunulira zoyenera, monga mowa kapena ether, kuti zikonzekere kukonzekera mankhwala.Mawonekedwe ambiri amakonzedwa ngati jekeseni njira yowonetsetsa kuti dosing yolondola.
Kutengedwa pamodzi, kupanga ndondomeko yapaclitaxelndi njira yovuta komanso yambiri yopangidwa kuti iwonetsetse chiyero chapamwamba ndi kuwongolera kwa mankhwala omaliza.Kuchita bwino kwa njirayi ndikofunika kwambiri kuti pakhale chithandizo chamankhwala chogwira mtima cha khansa ndipo motero nthawi zonse ikukonzedwa ndikukonzedwa kuti ikwaniritse zosowa zachipatala.
Zindikirani: Mapindu omwe angakhalepo komanso momwe angagwiritsire ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku ofalitsidwa.
Yunnan Hande Biotechnology Co., Ltd. yakhala ikuyang'ana kwambiri pakupanga paclitaxel kwa zaka 26, ndipo ndi wopanga palokha wa mankhwala odana ndi khansa a paclitaxel API ovomerezedwa ndi United States FDA, European EDQM, Australia TGA, China CFDA , India, Japan ndi mabungwe ena olamulira dziko.Yunnan Hande paclitaxel, malo ogulitsa, malonda a fakitale mwachindunji, talandiridwa kuti mufunse, 18187887160 (WhatsApp nambala yomweyo)
Nthawi yotumiza: Oct-13-2023