Makina oletsa khansa a Paclitaxel.Mukudziwa chiyani?

Paclitaxel ndi mankhwala odana ndi khansa omwe amagwiritsidwa ntchito pochiza mitundu yambiri ya khansa. Poyambirira adatengedwa ku khungwa la mtengo wa Pacific yew (Taxus pacifica) ndipo kenako amapangidwa ndi njira zopangira.Paclitaxelali m'gulu la mankhwala otchedwa microtubule stabilizers.

Njira yolimbana ndi khansa yapaclitaxelimakhudza mbali zambiri, makamaka izi:

1.Kuwonjezeka kwa microtubule kukhazikika: Paclitaxel imalepheretsa kukhazikika kwachibadwa kwa ma microtubules mwa kumangirira ku tubulin, yomwe ili mbali ya cytoskeleton.Izi zimapangitsa kuti ma microtubules alephere kusweka ndi kukonzanso, kuteteza kugawanika kwa maselo ndi kukula.Kugawanika kwa maselo a khansa ndi Mbali yofunika kwambiri ya khansa, kotero kulepheretsa kugawanika kwa maselo mwa kukhazikika kwa ma microtubules ndi njira yofunika kwambiri yolimbana ndi khansa ya paclitaxel.

2.Kumangidwa kwa ma cell: Paclitaxel imathanso kuyambitsa kumangidwa kwa ma cell, zomwe zimapangitsa kuti maselo a khansa atseke mugawo linalake la cell cycle, nthawi zambiri mitosis.Izi zimathandizanso kuchepetsa kukula ndi kugawanika kwa maselo a khansa.

3. Imalimbikitsa apoptosis: Paclitaxel ikhoza kulepheretsa kukula kwa khansa poyambitsa maselo a khansa omwe awonongeka kapena osadziwika kuti alowe mu apoptosis (programmed cell death) .Iyi ndi njira yachilengedwe ya imfa ya maselo yomwe imathandiza kuchotsa maselo osadziwika bwino.

4. Anti-angiogenesis:PaclitaxelZingathenso kulepheretsa kupangidwa kwa mitsempha yatsopano yamagazi kuzungulira maselo a khansa, zomwe ndizofunikira kuti chotupacho chikule ndi kufalikira. Mwa kupewa kupangika kwa mitsempha yatsopano yamagazi, kungathe kuchepetsa kutuluka kwa magazi ku chotupacho, motero kuchepetsa kukula kwa chotupacho.

Ponseponse, paclitaxel ndi mankhwala omwe amalepheretsa kukula ndi kugawanika kwa maselo a khansa, omwe amagwira ntchito pama cell a khansa kudzera m'njira zosiyanasiyana, motero amagwiritsidwa ntchito kwambiri pamitundu yambiri yamankhwala.

Zindikirani: Zopindulitsa zomwe zingachitike ndikugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku osindikizidwa.

Yunnan Hande Biotechnology Co., Ltd. yakhala ikuyang'ana kwambiri kupangapaclitaxelkwa zaka 26, ndipo ndi wodziimira pawokha wa mankhwala odana ndi khansa a paclitaxel API ovomerezeka ndi United States FDA, European EDQM, Australia TGA, China CFDA, India, Japan ndi mabungwe ena olamulira dziko.Yunnan Hande paclitaxel, malo ogulitsa ,kugulitsa mwachindunji kufakitale, talandilani kufunsa,18187887160(WhatsApp nambala yomweyo)