Kusiyana ndi ubwino pakati pa chilengedwe ndi semisynthetic paclitaxel

Paclitaxel ndi mankhwala ofunika kwambiri othana ndi khansa, ndipo kapangidwe kake kapadera komanso zochitika zachilengedwe zakopa chidwi cha asayansi.Malinga ndi gwero lake komanso njira yokonzekera, paclitaxel imatha kugawidwa kukhala paclitaxel yachilengedwe komanso semi-synthetic paclitaxel.Nkhaniyi ifotokoza za kusiyana ndi ubwino wake mwa awiriwo.

Gwero ndi njira yokonzekera

Natural paclitaxel:Natural paclitaxel imachokera ku mtengo wa Pacific yew (Taxus brevifolia). Mtengowu uli ndi paclitaxel wambiri, koma wochepa kwambiri, zomwe zimapangitsa kuti paclitaxel ikhale yochepa.

Semisynthetic paclitaxel:Semi-synthetic paclitaxel imapangidwa ndi kaphatikizidwe ka mankhwala kuchokera ku taxanes yotengedwa ku khungwa la taxus chinensis.Njirayi ingagwiritsidwe ntchito kupanga paclitaxel pamlingo waukulu kuti akwaniritse zosowa zachipatala.

Kapangidwe ka mankhwala

Ngakhale zachilengedwe za paclitaxel ndi semi-synthetic paclitaxel zimasiyana pang'ono ndi kapangidwe ka mankhwala, kapangidwe kake kake ndi kofanana, ndipo onse ndi diterpenoid alkaloids.

Biological ntchito ndi lachangu

Natural paclitaxel: Pazachipatala, paclitaxel yachilengedwe yawonetsedwa kuti ili ndi mphamvu yochiritsa pamakhansa osiyanasiyana, kuphatikiza khansa ya m'mawere, khansa ya m'mawere, khansa yamutu ndi khosi, komanso khansa ya m'mapapo. ya tubulin ndikuwononga ma cell microtubule network, motero kuletsa kuchulukana kwa ma cell ndikupangitsa apoptosis ya ma cell a khansa.

Semi-synthetic paclitaxel:Semi-synthetic paclitaxel ndi yofanana ndi mphamvu ya paclitaxel yachilengedwe komanso imakhala ndi ntchito yayikulu yolimbana ndi khansa.Kupanga misa ya semisynthetic paclitaxel kumatha kukulitsa chithandizo chamankhwala ndikupereka njira zambiri zothandizira odwala khansa.

Zotsatira zoyipa

Natural paclitaxel: Kawopsedwe wa paclitaxel wachilengedwe ndi wochepa, koma angayambitsebe zovuta zina, monga matupi awo sagwirizana, kuponderezedwa kwa mafupa ndi kuopsa kwa mtima.

Semi-synthetic paclitaxel:Zotsatira za semi-synthetic paclitaxel ndizofanana ndi za paclitaxel zachilengedwe. Onsewa amafunikira mankhwala omveka bwino malinga ndi momwe zinthu ziliri komanso malingaliro a dokotala kuti achepetse chiopsezo cha zovuta.

Chitukuko chamtsogolo

Ndi kupita patsogolo kosalekeza kwa sayansi ndi ukadaulo, kafukufuku wa paclitaxel ukukulanso. M'tsogolomu, asayansi ayesetsa kupeza njira zogwirira ntchito zapaclitaxel synthesis kuti apititse patsogolo kupanga kwake ndikuwongolera magwiridwe antchito azachipatala. Kupanga matekinoloje omwe akubwera monga genetic engineering ndi cell therapy, njira zochizira payekhapayekha za paclitaxel zithanso zotheka, motero kupatsa odwala khansa njira zochiritsira zolondola komanso zogwira mtima.

Mapeto

Onsepaclitaxel zachilengedwendisemisynthetic paclitaxelNgakhale kuti chiyambi chawo ndi njira zokonzekera ndizosiyana, amagawana zofanana mu kapangidwe ka mankhwala, biological zochitika ndi pharmacodynamics. M'kafukufuku wamtsogolo, asayansi apitiliza kuwunika momwe chilengedwe chimagwirira ntchito komanso madera ogwiritsira ntchito paclitaxel kuti abweretse chiyembekezo chamankhwala kwa odwala khansa.

Zindikirani: Zopindulitsa zomwe zingachitike ndikugwiritsa ntchito zomwe zafotokozedwa m'nkhaniyi zimachokera m'mabuku osindikizidwa.