10-DAB Semi-Synthetic Paclitaxel: Chochitika Chopambana Pankhani ya Mankhwala Osokoneza Bongo

Paclitaxel ndi mankhwala ofunikira omwe amagwiritsidwa ntchito kwambiri pochiza khansa, koma magwero ake achilengedwe ndi ochepa.Kuti akwaniritse kufunikira kwa paclitaxel pamsika wamankhwala, asayansi achita kafukufuku wambiri, ndi njira zopangira semi-synthetic kukhala njira yofunika kwambiri yopangira.Nkhaniyi ifotokoza za semi-synthesizing paclitaxel kuchokera ku 10-deacetylbaccatin III (10-DAB) ndikugogomezera kufunika kwake pankhani ya kaphatikizidwe ka mankhwala.

Paclitaxel, yemwe adadzipatula ku khungwa la mtengo wa Pacific yew, amadziwika chifukwa cha zinthu zake zotsutsana ndi khansa.Komabe, Pacific yew ndi zachilengedwe zopanda malire, zosakwanira kukwaniritsa zosowa zamakono zachipatala za paclitaxel.Kupanga njira zopangira semi-synthetic kwapangitsa kuti paclitaxel ikhale yotheka, ndi 10-deacetylbaccatin III kukhala wapakatikati wovuta.

Kukonzekera kwa 10-DAB mu Semi-Synthetic Paclitaxel:

10-DAB ndiyofunikira kwambiri panjira yopita ku paclitaxel ndipo imafunikira njira zingapo pokonzekera.Nthawi zambiri, kaphatikizidwe ka 10-DAB kumayamba ndi kalambulabwalo wachilengedwe wa paclitaxel, taxuyunnanine C, wotengedwa ku baccatin III.Baccatin III poyamba deacetylated kuti apereke 10-deacetylbaccatin III.Pambuyo pake, 10-deacetylbaccatin III imakumana ndi machitidwe angapo, kuphatikizapo hydrogenation, substitution, epoxidation, hydrolysis, ndi zina, potsirizira pake kusintha kukhala 10-DAB.

Kugwiritsa ntchito 10-DAB mu Semi-Synthetic Paclitaxel:

Kuphatikizika kwa 10-DAB kwatsegula njira yatsopano yopangira semi-synthesis ya paclitaxel, yopereka kukhazikika pakupanga mankhwala.Paclitaxel ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza mitundu yosiyanasiyana ya khansa, kuphatikizapo khansa ya m'mawere, m'mawere, ndi m'mapapo.Njira yopangira semi-synthetic imachepetsa mtengo wopangira mankhwala, ndikupangitsa njira yofunikirayi kuti ipezeke kwa odwala.

Pomaliza:

Njira yopangira semi-synthesizing paclitaxel kuchokera ku 10-DAB yapeza bwino kwambiri pakupanga mankhwala.Sizimangoyang'ana nkhani ya zochepa zachilengedwe za paclitaxel komanso zimathandizira kupanga bwino komanso kukhazikika.Ukadaulo uwu ukuyimira gawo lalikulu kwambiri popanga mankhwala oletsa khansa ndipo ali ndi chiyembekezo chakupita patsogolo kwachipatala kuti athe kuthana ndi matenda oopsa monga khansa.M'tsogolomu, ochita kafukufuku adzapitirizabe kukonzanso njira zophatikizirapo kuti azitha kuyendetsa bwino komanso kuchepetsa ndalama, potsirizira pake kupindula ndi odwala ambiri.

Zindikirani: Zopindulitsa zomwe zatchulidwa m'nkhaniyi zimachokera ku mabuku omwe amapezeka kwa anthu.

Kuwerenganso: Yunnan Hande Biotech Co., Ltd., yomwe kwa zaka 26 ikuyang'ana kwambiri pakupanga paclitaxel, ndi kampani yovomerezeka padziko lonse lapansi yopanga mankhwala opangira mankhwala a anticancer paclitaxel, ovomerezeka ndi mabungwe olamulira monga US FDA, European EDQM. , Australia TGA, China CFDA, India, Japan, ndi ena.Yunnan Hande Paclitaxel, yomwe ilipo, imagulitsidwa mwachindunji ndi wopanga.Chonde khalani omasuka kuyimbira mafunso pa +86 18187887160 (WhatsApp).